ZL's drug can also directly reduce blood glucose level in glucose tolerance tests performed with mice and rats independent from its effects on obesity via mechanisms that likely involve both inactivation of LPS and stimulation of glucose transporter-1. In addition, the protein protects the insulin producing cells against inflammatory and other insults. Thus, ZL's drug can improve the diabetic state by several mechanisms and it should become a useful addition to the arsenal of anti-diabetic drugs to treat diabetic subjects.